Ajou University School of Medicine
Department of Biomedical Sciences
at Ajou: 2016 - present
* First author / Corresponding author / Lab member
RNF213 variant and autophagic impairment: A pivotal link to endothelial dysfunction in Moyamoya disease
Shin HS*, Park GH, Choi ES, Park SY, Kim DS, Chang J, Hong JM
J Cereb Blood Flow Metab, Online ahead of print
TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1
Heo H*, Park H*, Lee MS, Kim J, Kim J, Jung S-Y, Kim SK, Lee S, Chang J
Autophagy, 20(5):1098-1113. May 2024
Neurofilament light chain and cardiac MIBG uptake as predictors for phenoconversion in isolated REM sleep behavior disorder
Park DG*, Kim JY*, Kim MS, Kim MH, An Y-S, Chang J, Yoon JH
J Neurol, 270(9):4393-4402, May 2023
Baseline Clinical and Biomarker Characteristics of Biobank Innovations for Chronic Cerebrovascular Disease With Alzheimer's Disease Study: BICWALZS
Roh HW*, Kim NR, Lee DG, Cheong JY, Seo SW, Choi SH, Kim EJ, Cho SH, Kim BC, Kim SY, Kim EY, Chang J, Lee SY, Yoon D, Choi JW, An YS, Kang HY, Shin H, Park B, Son SJ, Hong CH
Psychiatry Investig, 19(2):100-109, Jan 2022.
Association of plasma α-synuclein with cardiac 123I-MIBG scintigraphy in early Parkinson’s disease
Park DG*, Kang J*, An Y-S, Chang J, Yoon JH
Neurosci Lett, 770:136399, Jan 2022.
Plasma neurofilament light chain level and orthostatic hypotension in early Parkinson’s disease
Park DG*, Kim JW*, An Y-S, Chang J, Yoon JH
J Neural Transm, 128(12):1853-1861, Dec 2021
Identification of cathepsin D as a plasma biomarker for Alzheimer's disease
Kim JW*, Jung S-Y*, Kim Y, Heo H, Hong CH, Seo SW, Choi SH, Son SJ, Lee S, Chang J
Identification of BAG2 and cathepsin D as plasma biomarkers for Parkinson’s disease
Kang J*, Kim JW*, Heo H, Lee J, Park KY, Yoon JH, Chang J
Clin Transl Sci, 14(2):606-616, Mar 2021
Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion
Lee S*, Park H, Zhu PP, Jung SY, Blackstone C, Chang J
Sci Signal, 13 (613), eaau7500, Jan 2020
Selected as a cover paper of the issue
Cerebrospinal fluid levels of Aβ40 and Aβ42 are proportionately decreased in amyloid PET negative idiopathic normal-pressure hydrocephalus patients
Kim HJ*, Lim TS, Lee SM, Kim T, Kim Y, An Y, Youn YC, Park SA, Chang J, Moon SY
J Clin Neurol, 15 (3), 353-359, Jul 2019
Cigarette smoke condensate may disturb immune function with apoptotic cell death by impairing function of organelles in alveolar macrophages
Park EJ*, Lee HS, Lee SJ, Park YJ, Park SI, Chang J, Lee K
Toxicol In Vitro, 52, 351-364, Oct 2018
Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias
Denton K*, Mou Y, Xu CC, Shah D, Chang J, Blackstone C, Li XJ
Hum Mol Genet, 27 (14), 2517-2530, Jul 2018
Lung fibroblasts may play an important role in clearing apoptotic bodies of bronchial epithelial cells generated by exposure to PHMG-P-containing solution
Park EJ*, Park SJ, Kim S, Lee K, Chang J
Toxicol Lett, 286, 108-119, Apr 2018
Fibrous nanocellulose, crystalline nanocellulose, carbon nanotubes, and crocidolite asbestos elicit disparate immune responses upon pharyngeal aspiration in mice
Park EJ*, Khaliullin TO*, Shurin MR, Kisin ER, Yanamala N, Fadeel B, Chang J, Shvedova AA
J Immunotoxicol, 15 (1), 12-23, Dec 2018
Comparison of subchronic immunotoxicity of four different types of aluminum-based nanoparticles
Park EJ*, Lee SJ*, Lee G, Kim D, Yoon C, Lee B, Kim Y, Chang J, Lee K
J Appl Toxicol, 38 (4), 575-584, Apr 2018
Methylisothiazolinone may induce cell death and inflammatory response through DNA damage in human liver epithelium cells
Park EJ*, Kim S, Chang J
Environ Toxicol, 33 (2),156-166, Feb 2018
Ambient fine particulate matters induce cell death and inflammatory response by influencing mitochondria function in human corneal epithelial cells
Park EJ*, Chae JB, Lyu J, Yoon C, Kim S, Yeom C, Kim Y, Chang J
Environ Res, 159, 595-605, Nov 2017
Tissue distribution following 28-day repeated oral administration of aluminum-based nanoparticles with different properties and the in vitro toxicity
Park EJ*, Lee GH, Yoon C, Jeong U, Kim Y, Chang J, Kim DW
J Appl Toxicol, 37 (12), 1408-1419, Dec 2017
PLK4 phosphorylation of CP110 is required for efficient centriole assembly
Lee M*, Seo MY*, Chang J*, Hwang DS, Rhee K
Cell Cycle, 16 (12), 1225-1234, Jun 2017
Nano-sized iron particles may induce multiple pathways of cell death following generation of mistranscripted RNA in human corneal epithelial cells
Park EJ*, Che JB, Kang S, Lyu J, Jeong U, Yeom C, Kim, Y, Chang J
Toxicol In Vitro, 42, 348-357, Aug 2017
Pulmonary glass particles may persist in the lung suppressing function of immune cells
Park EJ*, Lee GH*, Kim JC, Lee S, Lee K, Lee BS, Chang J, Kim DW
Environ Toxicol, 32 (6), 1688-1700, Jun 2017
FAM21 directs SNX27-retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus
Lee S*, Chang J*, Blackstone C
at SNU and NIH: 2004 - 2015
Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease
Hirst J*, Edgar JR*, Esteves T, Darios F, Madeo M, Chang J, Roda RH, Dürr A, Anheim M, Gellera C, Li J, Züchner S, Mariotti C, Stevanin G, Blackstone C, Kruer MC, Robinson MS
Hum Mol Genet, 24 (17), 4984-96, Sep 2015
Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axonal development
Goyal U*, Renvoisé B*, Chang J, Blackstone C
PLoS One, 9 (11), e112428, Nov 2014
Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation
Chang J*, Lee S*, Blackstone C
J Clin Invest, 124 (12), 5249-62, Dec 2014
Highlighted in Editor's Picks in JCI Impact - December 2014
Interviewed by JCI: First Author Perspectives
Lysosomal abnormalities in hereditary spastic paraplegia types SPG15 and SPG11
Renvoisé B*, Chang J*, Singh R, Yonekawa S, FitzGibbon EJ, Mankodi A, Vanderver A, Schindler A, Toro C, Gahl WA, Mahuran DJ, Blackstone C, Pierson TM
Ann Clin Transl Neurol, 1 (6), 379-389, Jun 2014
Asymmetric spindle pole formation in CPAP-depleted mitotic cells
Lee M*, Chang J, Chang S, Lee KS, Rhee K
Biochem Biophys Res Commun, 444 (4), 644-50, Feb 2014
Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation
Chang J*, Lee S, Blackstone C
Proc Natl Acad Sci U S A, 110 (37), 14954-9, Sep 2013
Rab10 joins the ER social network
Chang J*, Blackstone C
Nat Cell Biol, 15 (2), 135-6, Feb 2013
Essential role of Cenexin1, but not Odf2, in ciliogenesis
Chang J*, Seo SG*, Lee KH, Nagashima K, Bang JK, Kim BY, Erikson RL, Lee KW, Lee HJ, Park JE, and Lee KS
Cell Cycle, 12 (4), 655-62, Feb 2013
Highlighted in News & Views in Cell Cycle 12 (6), 869
Highlighted in News & Views in Cell Cycle 12 (7), 1021
MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis
Lee S*, Chang J, Renvoisé B, Tipirneni A, Yang S, Blackstone C
Mol Biol Cell, 23 (22), 4347-61, Nov 2012
PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle
Chang J*, Cizmecioglu O, Hoffmann I, Rhee K
EMBO J, 29 (14), 2395-406, Jul 2010
A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization
Kim K*, Lee S*, Chang J*, Rhee K
Exp Cell Res, 314 (20), 3692-700, Dec 2008
NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi
Yoo JC*, Chang JR, Kim SH, Jang SK, Wolgemuth DJ, Kim K, Rhee K